СОВРЕМЕННЫЙ ВЗГЛЯД НА ПРОБЛЕМУ ЛЕЧЕНИЯ ИНФЕКЦИОННОГО ПЕРИТОНИТА КОШЕК
УДК: 619:579:636.8.045 DOI: 10.31588/2413_4201_1883_2_254_130
Ключевые слова:
инфекционный перитонит кошек, FIP, этиотропная терапия, GS-441524, «Коронакэт»Аннотация
Инфекционный перитонит кошек (Feline infectious peritonitis (FIP)) — фатальная иммуноопосредованная вирусная болезнь кошачьих. Болеют кошки всех возрастов, но наиболее чувствительны молодые животные в возрасте до 2 лет, а также взрослые старше 10 лет. Прогноз для кошки с FIP крайне неблагоприятный — 99% летальный исход. В данной статье представлен современный взгляд на проблему лечения инфекционного перитонита кошек. Представлен краткий обзор препаратов, предложенных для симптоматического и этиотропного лечения болезни. Из обзора можно сделать выводы, что большинство препаратов, предложенных для этиотропного лечения FIP, обладают слабой доказательной базой и требуют проведения дальнейших исследований. Одним из наиболее эффективных средств показал себя нуклеозидный аналог GS-441524, разработанный в компании Gilead Sciences. На основе GS-441524 создан зарегистрированный препарат «Коронакэт» (разработчик ООО «ВЕТУЧАСТОК», производитель — филиал «Промветсервис-Альба» ООО «Промветсервис»).
Литература
Инструкция по применению ветеринарного препарата «Коронакэт». -- Текст: электронный // Коронакэт: сайт препарата. --URL: https://fip-cat.ru/ (23.10.22).
Барсегян, Л. С. Инфекционный вирусный перитонит кошек (обзор литературы) / Л. С. Барсегян, О. И. Сухарев, Е. В. Куликов // Актуальные вопросы ветеринарной биологии. -- 2015. -- №1(25). -- С. 16-23.
Куликов, Е. В. Патологоанатомическая характеристика вирусного перитонита кошек / Е. В. Куликов, Ю. А. Ватников, Н. В. Сахно, И. А. Попова, Л. А. Гнездилова [и др.] // Российский журнал сельскохозяйственных и социально-экономических наук. -- 2017. -- № 4(64). -- C. 270-280.
Пальцева, Е. Д. Коронавирусы в популяции домашних кошек / Е. Д. Пальцева, В. И. Плешакова // Вестник Омского государственного аграрного университета. -- 2022. -- № 1 (45). -- С. 94-101.
Равилов, Р.Х. Хламидиоз собак и кошек / Р. Х. Равилов // Практикум ветеринарного врача. -- Москва, 2006. -- 126 с.
Соломахина, Л. А. Офтальмологические проявления вирусного перитонита кошек / Л. А. Соломахина, О. О. Смирнова // VetPharma. -- 2017. -- № 1. -- С. 52-63.
Терехова, Ю. О. Современный взгляд на диагностику, лечение и профилактику инфекционного перитонита кошек / Ю. О. Терехова, В. В. Цибезов, О. А. Верховский, Н. А. Рахманина, А. Л. Елаков // VetPharma. -- 2014. -- № 2(18). -- С. 46-53.
Amici, C. Indomethacin has a potent antiviral activity against SARS coronavirus / C. Amici, A. Di Caro, A. Ciucci, L. Chiappa [et all.] // Antivir Ther. -- 2006. -- №11(8). -- PP. 1021-1030.
Barlough, J. E. Effectiveness of three antiviral agents against FIP virus in vitro / J. E. Barlough, F. W. Scott // Vet Rec. -- 1990. -- № 126(22). -- PP. 556-558.
Dickinson, P. J. Antiviral treatment using the adenosine nucleoside analogue GS-441524 in cats with clinically diagnosed neurological feline infectious peritonitis / P. J. Dickinson, M. Bannasch, S. M. Thomasy, V. D. Murthy [et all.] // J Vet Intern Med. -- 2020. -- №34(4). -- PP. 1587-1593.
Doki, T. In vitro antiviral effects of GS-441524 and itraconazole combination against feline infectious peritonitis virus / T. Doki, K. Takahashi, N. Hasegawa, T. Takano // Res Vet Sci. -- 2022. -- №144. -- PP. 27-33.
Doki, T. Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis / T. Doki, T. Takano, K. Kawagoe, A. Kito, T. Hohdatsu // Res Vet Sci. -- 2016. -- №104. -- PP. 17-23.
Doki, T. Therapeutic effect of an anti-human-TNF-alpha antibody and itraconazole on feline infectious peritonitis / T. Doki, M. Toda, N. Hasegawa, T. Hohdatsu, T. Takano // Arch Virol. -- 2020. -- №165(5). -- PP. 1197-1206.
Feline Coronavirus & Feline Infectious Peritonitis. ABCD Guideline with literature review / European Advisory Board on Cat Diseases (ABCD); [updated by Séverine Tasker et al.]. -- 2022. -- 82 p.
Fischer Y. Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis / Y. Fischer, S. Ritz, K. Weber, C. Sauter-Louis, K. Hartmann // J. Vet. Intern. Med. -- 2011. -- № 25(6). -- PP. 1270-1276.
Gil, S. Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter / S. Gil, R. O. Leal, A. Duarte, D. Mc Gahie [et all.] // Res Vet Sci. -- 2013. -- №94(3). -- PP. 753-763.
Hsieh, L. E. Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus / L. E. Hsieh, C. N. Lin, B. L. Su, T. R. Jan [et all.] // Antiviral Res. -- 2010. -- №88(1). -- PP. 25-30.
Ishida, T. Use of recombinant feline interferon and glucocorticoid in the treatment of feline infectious peritonitis / T. Ishida, A. Shibanai, S. Tanaka, K. Uchida, M. Mochizuki // J Feline Med Surg. -- 2004. -- №6(2). -- PP. 107-109.
Kim, Y. Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor / Y. Kim, H. Liu, A. C. Galasiti Kankanamalage, S. Weerasekara // PLoS Pathog. -- 2016. -- № 12(3) -- e1005531.
Krentz, D. Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524 / D. Krentz, K. Zenger, M. Alberer, S. Felten [et all.] // Viruses. -- 2021. -- №13(11).
Mc Donagh, P. Identification and characterisation of small molecule inhibitors of feline coronavirus replication / P. Mc Donagh, P. A. Sheehy, J. M. Norris // Vet. Microbiol. -- 2014. -- № 174(3-4). -- PP. 438-447.
Murphy, B. G. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies / B. G. Murphy, M. Perron, E. Murakami, K. Bauer [et all.] // Vet. Microbiol. -- 2018. -- № 219. -- PP. 226-233.
Ng, S. W. Vitro Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats / S. W. Ng, G. T. Selvarajah, M. Z. Hussein, S. K. Yeap, A. R. Omar // Biomed Res Int. -- 2020. -- 3012198.
Pedersen, N. C. An update on feline infectious peritonitis: virology and immunopathogenesis / N. C. Pedersen // Vet J. -- 2014. -- №201(2). -- PP. 123-132.
Pedersen N. C. The Long History of Beta-d-n4-Hydroxycytidine and Its Modern Application to Treatment of COVID-19 in People and FIP in Cats / N. C. Pedersen // Sock it to Fip. [(accessed on 8 October 2022)]. Available online: https://sockfip.org/https-sockfip-org-wp-content-uploads-2022-04-the-long-history-of-beta-d-n4-hydroxycytidine-and-its-modern-application-to-treatment-of-covid-19-in-people-and-fip-in-cats-v2-pdf/.
Pedersen, N. C. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis / N. C. Pedersen, Y. Kim, H. Liu, A. C. Galasiti Kankanamalage [et al.] // J. Feline Med. Surg. -- 2018. -- № 20(4). -- PP. 378-392.
Pedersen, N. C. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis / N. C. Pedersen, M. Perron, M. Bannasch, E. Montgomery [et al.] // J Feline Med Surg. -- 2019. -- № 21(4). -- PP. 271-281.
Ritz, S. Effect of feline interferon-omega on the survival time and quality of life of cats with feline infectious peritonitis / S. Ritz, H. Egberink, K. Hartmann // J. Vet. Intern. Med. -- 2007. -- № 21(6). -- PP. 1193-1197.
Takano, T. Antiviral activity of itraconazole against type I feline coronavirus infection / T. Takano, M. Akiyama, T. Doki, T. Hohdatsu // Vet. Res. -- 2019. -- № 50(1). -- 5 p.
Takano, T. "Possible" involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis / T. Takano, T. Hohdatsu [et al.] // Vet. Microbiol. -- 2007. -- № 119(2-4). -- PP. 121-131.
Takano T. Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo / T. Takano [et al.] // Antiviral Res. -- 2013. -- №99(2). -- PP. 100-107.
Takano, T. Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II / T. Takano, K. Nakano, T. Doki, T. Hohdatsu // Arch Virol. -- 2015. -- №160(5). -- PP. 1163-1170.
Takano, T. Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection / T. Takano, K. Satoh, T. Doki, T. Tanabe, T. Hohdatsu // Viruses. -- 2020. -- №12(5).
Tanaka, Y. Suppression of feline coronavirus replication in vitro by cyclosporin A / Y. Tanaka, Y. Sato, S. Osawa, M. Inoue, S. Tanaka, T. Sasaki // Vet. Res. -- 2012. -- №43(1). -- 41 p.
Taylor, S. S. ISFM Protocol: An update on a treatment of feline infectious peritonitis in the UK. bit.ly / S. S. Taylor [et al.] // ISFMFIP protocol Accessed 20th February 2022.
Watari, T. Effect of thromboxane synthetase inhibitor on feline infectious peritonitis in cats / T. Watari, T. Kaneshima, H. Tsujimoto, K. Ono, A. Hasegawa // J. Vet. Med. Sci. -- 1998. -- №60(5). -- PP. 657-659.
Weiss, R. C. Effect of interferon or Propionibacterium acnes on the course of experimentally induced feline infectious peritonitis in specific-pathogen-free and random-source cats / R. C. Weiss, N. R. Cox, T. Oostrom-Ram // Am. J. Vet. Res. -- 1990. -- № 51(5). -- PP. 726-733.
Yin, Y. A retrospective study of clinical and laboratory features and treatment on cats highly suspected of feline infectious peritonitis in Wuhan, China / Y. Yin, T. Li, C. Wang, X. Liu [et al.] // Sci Rep. -- 2021. -- № 11(1). -- 5208 p.
Instructions for the use of the veterinary drug "Coronacat". -- Text: electronic // Coronacat: drug website. -- URL: https://fip-cat.ru/ (23.10.22).
Barsegyan, L. S. Infectious viral peritonitis of cats (literature review) / L. S. Barsegyan, O. I. Sukharev, E. V. Kulikov // Actual issues of veterinary biology. -- 2015. -- No. 1(25). -- P. 16-23.
Kulikov, E. V. Pathological and anatomical characteristics of viral peritonitis in cats / E. V. Kulikov, Yu. A. Vatnikov, N. V. Sakhno, I. A. Popova, L. A. Gnezdilova [et al.] // Russian Journal of Agricultural and Socio-Economic Sciences. -- 2017. -- No. 4(64). -- P. 270-280.
Paltseva, E. D. Coronaviruses in the population of domestic cats / E. D. Paltseva, V. I. Pleshakov // Bulletin of Omsk State Agrarian University. -- 2022. -- No. 1 (45). -- P. 94-101.
Ravilov, R.Kh. Chlamydia of dogs and cats / R. Kh. Ravilov // Workshop of a Veterinarian. -- Moscow, 2006. -- 126 p.
Solomakhina, L. A. Ophthalmological manifestations of viral peritonitis in cats / L. A. Solomakhina, O. O. Smirnova // VetPharma. -- 2017. -- No. 1. -- P. 52-63.
Terekhova, Yu. O. Modern view on diagnosis, treatment and prevention of feline infectious peritonitis / Yu. O. Terekhova, V. V. Tsibezov, O. A. Verkhovsky, N. A. Rakhmanina, A. L. Elakov // VetPharma. -- 2014. -- No. 2(18). -- P. 46-53.
Amici, C. Indomethacin has a potent antiviral activity against SARS coronavirus / C. Amici, A. Di Caro, A. Ciucci, L. Chiappa [et all.] // Antivir Ther. -- 2006. -- No. 11(8). -- P. 1021-1030.
Barlough, J. E. Effectiveness of three antiviral agents against FIP virus in vitro / J. E. Barlough, F. W. Scott // Vet Rec. -- 1990. -- No. 126(22). -- P. 556-558.
Dickinson, P. J. Antiviral treatment using the adenosine nucleoside analogue GS-441524 in cats with clinically diagnosed neurological feline infectious peritonitis / P. J. Dickinson, M. Bannasch, S. M. Thomasy, V. D. Murthy [et all.] // J Vet Intern Med. -- 2020. -- No. 34(4). -- P. 1587-1593.
Doki, T. In vitro antiviral effects of GS-441524 and itraconazole combination against feline infectious peritonitis virus / T. Doki, K. Takahashi, N. Hasegawa, T. Takano // Res Vet Sci. -- 2022. -- No. 144. -- P. 27-33.
Doki, T. Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis / T. Doki, T. Takano, K. Kawagoe, A. Kito, T. Hohdatsu // Res Vet Sci. -- 2016. -- No. 104. -- P. 17-23.
Doki, T. Therapeutic effect of an anti-human-TNF-alpha antibody and itraconazole on feline infectious peritonitis / T. Doki, M. Toda, N. Hasegawa, T. Hohdatsu, T. Takano // Arch Virol. -- 2020. -- No. 165(5). -- P. 1197-1206.
Feline Coronavirus & Feline Infectious Peritonitis. ABCD Guideline with literature review / European Advisory Board on Cat Diseases (ABCD); [updated by Séverine Tasker et al.]. -- 2022. -- 82 p.
Fischer Y. Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis / Y. Fischer, S. Ritz, K. Weber, C. Sauter-Louis, K. Hartmann // J. Vet. Intern. Med. -- 2011. -- No. 25(6). -- P. 1270-1276.
Gil, S. Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter / S. Gil, R. O. Leal, A. Duarte, D. Mc Gahie [et all.] // Res Vet Sci. -- 2013. -- No. 94(3). -- P. 753-763.
Hsieh, L. E. Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus / L. E. Hsieh, C. N. Lin, B. L. Su, T. R. Jan [et all.] // Antiviral Res. -- 2010. -- No. 88(1). -- P. 25-30.
Ishida, T. Use of recombinant feline interferon and glucocorticoid in the treatment of feline infectious peritonitis / T. Ishida, A. Shibanai, S. Tanaka, K. Uchida, M. Mochizuki // J Feline Med Surg. -- 2004. -- No. 6(2). -- P. 107-109.
Kim, Y. Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor / Y. Kim, H. Liu, A. C. Galasiti Kankanamalage, S. Weerasekara // PLoS Pathog. -- 2016. -- No. 12(3) -- e1005531.
Krentz, D. Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524 / D. Krentz, K. Zenger, M. Alberer, S. Felten [et all.] // Viruses. -- 2021. -- No. 13(11).
Mc Donagh, P. Identification and characterisation of small molecule inhibitors of feline coronavirus replication / P. Mc Donagh, P. A. Sheehy, J. M. Norris // Vet. Microbiol. -- 2014. -- No. 174(3-4). -- P. 438-447.
Murphy, B. G. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies / B. G. Murphy, M. Perron, E. Murakami, K. Bauer [et all.] // Vet. Microbiol. -- 2018. -- No. 219. -- P. 226-233.
Ng, S. W. Vitro Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats / S. W. Ng, G. T. Selvarajah, M. Z. Hussein, S. K. Yeap, A. R. Omar // Biomed Res Int. -- 2020. -- 3012198.
Pedersen, N. C. An update on feline infectious peritonitis: virology and immunopathogenesis / N. C. Pedersen // Vet J. -- 2014. -- No. 201(2). -- P. 123-132.
Pedersen N. C. The Long History of Beta-d-n4-Hydroxycytidine and Its Modern Application to Treatment of COVID-19 in People and FIP in Cats / N. C. Pedersen // Sock it to Fip. [(accessed on 8 October 2022)]. Available online: https://sockfip.org/https-sockfip-org-wp-content-uploads-2022-04-the-long-history-of-beta-d-n4-hydroxycytidine-and-its-modern-application-to-treatment-of-covid-19-in-people-and-fip-in-cats-v2-pdf/.
Pedersen, N. C. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis / N. C. Pedersen, Y. Kim, H. Liu, A. C. Galasiti Kankanamalage [et al.] // J. Feline Med. Surg. -- 2018. -- No. 20(4). -- P. 378-392.
Pedersen, N. C. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis / N. C. Pedersen, M. Perron, M. Bannasch, E. Montgomery [et al.] // J Feline Med Surg. -- 2019. -- No. 21(4). -- P. 271-281.
Ritz, S. Effect of feline interferon-omega on the survival time and quality of life of cats with feline infectious peritonitis / S. Ritz, H. Egberink, K. Hartmann // J. Vet. Intern. Med. -- 2007. -- No. 21(6). -- P. 1193-1197.
Takano, T. Antiviral activity of itraconazole against type I feline coronavirus infection / T. Takano, M. Akiyama, T. Doki, T. Hohdatsu // Vet. Res. -- 2019. -- No. 50(1). -- 5 p.
Takano, T. "Possible" involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis / T. Takano, T. Hohdatsu [et al.] // Vet. Microbiol. -- 2007. -- No. 119(2-4). -- P. 121-131.
Takano T. Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo / T. Takano [et al.] // Antiviral Res. -- 2013. -- No. 99(2). -- P. 100-107.
Takano, T. Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II / T. Takano, K. Nakano, T. Doki, T. Hohdatsu // Arch Virol. -- 2015. -- No. 160(5). -- P. 1163-1170.
Takano, T. Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection / T. Takano, K. Satoh, T. Doki, T. Tanabe, T. Hohdatsu // Viruses. -- 2020. -- No. 12(5).
Tanaka, Y. Suppression of feline coronavirus replication in vitro by cyclosporin A / Y. Tanaka, Y. Sato, S. Osawa, M. Inoue, S. Tanaka, T. Sasaki // Vet. Res. -- 2012. -- No. 43(1). -- 41 p.
Taylor, S. S. ISFM Protocol: An update on a treatment of feline infectious peritonitis in the UK. bit.ly / S. S. Taylor [et al.] // ISFMFIP protocol Accessed 20th February 2022.
Watari, T. Effect of thromboxane synthetase inhibitor on feline infectious peritonitis in cats / T. Watari, T. Kaneshima, H. Tsujimoto, K. Ono, A. Hasegawa // J. Vet. Med. Sci. -- 1998. -- No. 60(5). -- P. 657-659.
Weiss, R. C. Effect of interferon or Propionibacterium acnes on the course of experimentally induced feline infectious peritonitis in specific-pathogen-free and random-source cats / R. C. Weiss, N. R. Cox, T. Oostrom-Ram // Am. J. Vet. Res. -- 1990. -- No. 51(5). -- P. 726-733.
Yin, Y. A retrospective study of clinical and laboratory features and treatment on cats highly suspected of feline infectious peritonitis in Wuhan, China / Y. Yin, T. Li, C. Wang, X. Liu [et al.] // Sci Rep. -- 2021. -- No. 11(1). -- 5208 p.
