DYNAMICS OF THE INFLUENCE OF NPY ON AMPLITUDE-TEMPORAL INDICATORS OF ISOMETRIC CONTRACTION OF ATRIAL MYOCARDIUM
УДК: 612.17 DOI: 10.31588/2413_4201_1883_4_260_105
Keywords:
neuropeptide Y, heart, myocardium, isometric measurement, evoked spontaneous activityAbstract
The purpose of the study was to study the dynamics of the influence of neuropeptide Y (NPY) on the frequency and amplitude-time parameters of isometric contraction of the atrial myocardium of rats in early postnatal ontogenesis. In this work, we studied the effect of a non-selective NPY agonist on the frequency of spontaneous activity and contractility of the rat atrial myocardium at different stages of the formation of sympathetic innervation. NPY in 7-day-old animals has a multidirectional effect on the frequency of spontaneous activity and significantly reduces it in 100-day-old animals. The main parameters of isometric reduction are reduced with the addition of NPY compared to control values.
References
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Tatemoto, K. Neuropeptide Y—a novel brain peptide with structural similarities to peptide Yy and pancreatic polypeptide / K. Tatemoto, M. Carlquist, V. Mutt // Nature. – 1982. – V. 296. – P. 659-660.
