MORPHOLOGICAL CHANGES IN ADRENAL CORTEX OVER TIME OF SKIN BURN INJURY
УДК: 576.31 DOI: 10.31588/2413_4201_1883_1_257_9
Keywords:
morphology, adrenal glands, hypothalamic-pituitary-adrenal axis, adrenocorticocytes, thermal burnAbstract
The purpose of the study was the study of the morphological features of the adrenal cortex of rats in the dynamics of burn injury of the skin. Morphological features of the adrenal cortex were assessed by the degree of dystrophic changes. In the early stages of the burn injury (2-7 days), the development of dystrophic processes of adrenocorticocytes occurred. Morphological changes in the cortical matter of the adrenal glands in the dynamics of burn injury are undulating and accompanied by signs of swelling and dystrophy against the background of the emerging functional tension. By 10 days, a decrease in structural transformations in the adrenal cortex was established, which is due to a high level of stress-reactivity and activation of protective-adaptive reactions of the cortical substance. An increase in the quantitative indicators of corticocytes and their nuclei indicates an increase in secretory activity affecting the nuclear apparatus during their cell cycle.
References
Дзевульская, И. В. Морфологические изменения коры надпочечников крыс при экспериментальном локальном термическом ожоге / И. В. Дзевульская, А. И. Ковальчук, А. В. Маликов // Морфологические ведомости. -- 2014. -- № 1. -- С. 39-45.
Дзевульская, И. В. Влияние гиперосмолярных растворов на микроциркуляцию в коре надпочечников при термическом ожоге у крыс / И. В. Дзевульская А. В. Маликов, В. Н. Титаренко // Вісник проблем біології і медицини. -- 2014. -- № 3(2). -- С. 289-293.
Закиров, Д. З. Изменения функции гипоталамо-гипофизарно-адреналовой системы при одновременном действии высокой температуры и гипоксии / Д. З. Закиров, Н. С. Матющенко // Вестник Кыргызско-Российского Славянского университета. -- 2014. -- Т. 14. -- № 5. -- С. 51-54.
Исламов, Ш. Морфологические изменения надпочечников при однократном воздействии хлората магния / Ш. Исламов, М. Якубов, А. Норжигитов // Журнал гепато-гастроэнтерологических исследований. -- 2021. -- Т. 2. -- №. 3.1. -- С. 16-21.
Cuffe, J. S. Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring / J. S. Cuffe, E. L. Turton, L. K. Akison, H. Bielefeldt-Ohmann, K. M. Moritz // J. Endocrinol. -- 2017. -- V. 232(1). -- P. 37-48. -- doi: 10.1530/JOE-16-0417. Epub 2016 Oct 17. PMID: 27754933.
Dou, J. Heat Stress Impairs the Physiological Responses and Regulates Genes Coding for Extracellular Exosomal Proteins in Rat / J. Dou, A. Khan, M. Z. Khan, S. Mi [et al.] // Genes (Basel). -- 2020. -- V. 3. -- P. 306. -- doi: 10.3390/genes11030306. PMID: 32183190; PMCID: PMC7140893.
Swierczynska, M. M. Changes in morphology and function of adrenal cortex in mice fed a highfat diet / M. M. Swierczynska, I. Mateska, M. Peitzsch [et al.] // Int. J. Obes. -- 2015. -- V. 39(2). -- P. 321-330.
Dzevulskaya, I. V. Morphological changes in the adrenal cortex of rats in experimental local thermal burn / I. V. Dzevulskaya, A. I. Kovalchuk, A. V. Malikov // Morphological Reports. -- 2014. -- No. 1. -- P. 39-45.
Dzevulskaya, I. V. The influence of hyperosmolar solutions on microcirculation in the adrenal cortex during thermal burn in rats / I. V. Dzevulskaya, A. V. Malikov, V. N. Titarenko // Bulletin of Problems of Biology and Medicine. -- 2014. -- No. 3(2). -- P. 289-293.
Zakirov, D. Z. Changes in the function of the hypothalamic-pituitary-adrenal system under the simultaneous action of high temperature and hypoxia / D. Z. Zakirov, N. S. Matyushchenko // Bulletin of the Kyrgyz-Russian Slavic University. -- 2014. -- Vol. 14. -- No. 5. -- P. 51-54.
Islamov, Sh. Morphological changes of adrenal glands under a single exposure to magnesium chlorate / Sh. Islamov, M. Yakubov, A. Norzhigitov // Journal of Hepato-Gastroenterological Research. -- 2021. -- Vol. 2. -- No. 3.1. -- P. 16-21.
Cuffe, J. S. Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring / J. S. Cuffe, E. L. Turton, L. K. Akison, H. Bielefeldt-Ohmann, K. M. Moritz // J. Endocrinol. -- 2017. -- V. 232(1). -- P. 37-48. -- doi: 10.1530/JOE-16-0417. Epub 2016 Oct 17. PMID: 27754933.
Dou, J. Heat Stress Impairs the Physiological Responses and Regulates Genes Coding for Extracellular Exosomal Proteins in Rat / J. Dou, A. Khan, M. Z. Khan, S. Mi [et al.] // Genes (Basel). -- 2020. -- V. 3. -- P. 306. -- doi: 10.3390/genes11030306. PMID: 32183190; PMCID: PMC7140893.
Swierczynska, M. M. Changes in morphology and function of adrenal cortex in mice fed a highfat diet / M. M. Swierczynska, I. Mateska, M. Peitzsch [et al.] // Int. J. Obes. -- 2015. -- V. 39(2). -- P. 321-330.
