COMPARATIVE STUDY OF THE FORMATION OF THE IMMUNE RESPONSE CAUSED BY VACCINES AGAINST AVIAN INFLUENZA (H9) OF CHICKENS, INCLUDING DIFFERENT STRAINS
УДК: 619:616.98:578.832.1/085.371:636.52 DOI: 10.31588/2413_4201_1883_4_256_9
Keywords:
poultry farming, veterinary medicine, vaccination, low pathogenic avian influenza, immunization, vaccine strains, immunityAbstract
A comparative study of the formation of the immune response induced by vaccines against avian influenza (H9) in chickens, including strains A/chicken/UAE/415/99 subline G1-like and A/chicken/Amursky/03/12/H9N2 subline Y280-like, is presented. It has been established that the use of the vaccine against avian influenza (H9N2), including the A/chicken/UAE/415/99 strain of the G1-like subline, makes it possible to ensure 100 % formation of the immune response. Compared to the vaccine against avian influenza (H9N2), which includes the A/chicken/Amursky/03/12/H9N2 strain of the Y280-like subline, its use can increase the intensity of immunity by an average of 45.2 % and the uniformity of antibody titers by 24.8 %. Immunization of poultry against avian influenza with the vaccine against avian influenza (H9N2), including the A/chicken/UAE/415/99 strain of the G1-like subline for every 100,000 heads, due to an increase in the survival rate of birds and a higher level of hatching of chickens, allows to obtain a positive economic effect at the level 5010446.38 rubles, the economic efficiency of veterinary measures is 8.08 rubles. for one ruble of expenses.
References
Вакцины против гриппа птиц в птицеводстве / Л. В. Костина, А. Д. Забережный, Т. В. Гребенникова [и др.] // Вопросы вирусологии. -- 2017. -- Т. 62, № 2. -- С. 53-60. -- DOI 10.18821/0507-4088-2017-62-2-53-60. -- EDN YJKHEP.
Волков, М. Высоко- и низкопатогенный грипп птиц / М. Волков // Животноводство России. -- 2021. -- № S3. -- С. 50-54. -- DOI 10.25701/ZZR.2021.97.56.003. -- EDN JKTONY.
Журавель, Н. А. Цифровизация методологии экономической оценки внедрения инновационных методов и средств ветеринарного применения в птицеводство / Н. А. Журавель, А. В. Мифтахутдинов // Достижения науки и техники АПК. -- 2019. -- Т. 33, № 11. -- С. 91-94. -- DOI 10.24411/0235-2451-2019-11120. -- EDN RVUVQH.
Ирза, В. Н. Cитуация по особо опасным вирусным болезням в промышленном птицеводстве Российской Федерации / В. Н. Ирза, М. С. Волков, А. В. Варкентин // Птица и птицепродукты. -- 2020. -- № 2. -- С. 50-52. -- DOI 10.30975/2073-4999-2020-22-2-50-52. -- EDN DEMQOO.
Ирза, В. Н. Об обострении эпизоотической ситуации по высокопатогенному гриппу птиц в России в 2020 г / В. Н. Ирза, М. С. Волков, А. В. Варкентин // Птица и птицепродукты. -- 2020. -- № 6. -- С. 16-20. -- DOI 10.30975/2073-4999-2020-22-6-16-20. -- EDN ZEPPWB.
Клинический случай низкопатогенного гриппа птиц Н9N2 на птицефабрике яичного направления / А. В. Варкентин, В. Н. Ирза, М. С. Волков, Л. А. Демченко // Птица и птицепродукты. -- 2020. -- № 3. -- С. 10-13. -- DOI 10.30975/2073-4999-2020-22-3-10-13. -- EDN DRCGKD.
Сравнение иммуногенной активности вакцин против низкопатогенного гриппа птиц подтипа H9N2, изготовленных на основе вирусов генетических линий G1 и Y280 / С. В. Фролов, Л. О. Щербакова, Н. В. Мороз [и др.] // Ветеринария сегодня. -- 2021. -- № 3(38). -- С. 224-229. -- DOI 10.29326/2304-196X-2021-3-38-224-229. -- EDN DQHCCA.
A global perspective on h9n2 avian influenza virus / T. P. Peacock, J. James, J. E. Sealy, M. Iqbal // Viruses. -- 2019. -- Vol. 11, No. 7. -- P. 620. -- DOI 10.3390/v11070620. -- EDN CRZZFS.
Avian influenza vaccines: a practical review in relation to their application in the field with a focus on the Asian experience / M. Peyre, G. Fusheng, S. Desvaux, F. Roger // Epidemiol. Infect, 2009. -- 137 (1). -- Р. 1-21. -- DOI 10.1017/S0950268808001039
Comparison of the Effectiveness of Two Different Vaccination Regimes for Avian Influenza H9N2 in Broiler Chicken / S. Talat, R. R. Abouelmaatti, R. Almeer, M. M. Abdel-Daim, W. K. Elfeil // ANIMALS, 2020. -- T. 10. -- № 10. --DOI 10.3390/ani10101875
Evaluation of vaccination strategies to control an avian influenza outbreak in French poultry production networks using EVACS tool / C. Hautefeuille, B. Azzouguen, S. Mouchel, G. Dauphin, M. Peyre // Preventive veterinary medicine, 2020. -- T. 184. -- DOI: 10.1016/j.prevetmed.2020.105129
Spackman, E. Practical aspects of vaccination of poultry against avian influenza virus / E. Spackman, M. J. Pantin-Jackwood // Veterinary Journal, 2014. -- Vol. 202. -- No 3. -- P. 408-415. -- -- DOI 10.1016/j.tvjl.2014.09.017.
Status and Challenges for Vaccination against Avian H9N2 Influenza Virus in China / J. Dong, Y. Zhou, J. Pu, L. Liu // Life, 2022. -- 12. -- 1326. -- DOI: 10.3390/life12091326
The molecular basis of antigenic variation among a(H9N2) avian influenza viruses / T. P. Peacock, W. T. Harvey, J. R. Sadeyen, R. Reeve, M. Iqbal // Emerg Microbes Infect, 2018. -- № 7;7 (1):176. -- DOI 10.1038/s41426-018-0178-y.
Vaccines against avian influenza in poultry / L. V. Kostina, A. D. Zaberzhny, T. V. Grebennikova [et al.] // Problems of Virology. -- 2017. -- Vol. 62, No. 2. -- P. 53-60. -- DOI 10.18821/0507-4088-2017-62-2-53-60. -- EDN YJKHEP.
Volkov, M. Highly and low pathogenic avian influenza / M. Volkov // Animal Husbandry of Russia. -- 2021. -- No. S3. -- P. 50-54. -- DOI 10.25701/ZZR.2021.97.56.003. -- EDN JKTONY.
Zhuravel, N. A. Digitalization of the methodology for economic evaluation of the introduction of innovative methods and means of veterinary application in poultry farming / N. A. Zhuravel, A. V. Miftakhutdinov // Achievements of Science and Technology of the Agro-Industrial Complex. -- 2019. -- Vol. 33, No. 11. -- P. 91-94. -- DOI 10.24411/0235-2451-2019-11120. -- EDN RVUVQH.
Irza, V. N. Situation on especially dangerous viral diseases in the industrial poultry industry of the Russian Federation / V. N. Irza, M. S. Volkov, A. V. Varkentin // Poultry and Poultry Products. -- 2020. -- No. 2. -- P. 50-52. -- DOI 10.30975/2073-4999-2020-22-2-50-52. -- EDN DEMQOO.
Irza, V. N. On the aggravation of the epizootic situation on highly pathogenic avian influenza in Russia in 2020 / V. N. Irza, M. S. Volkov, A. V. Varkentin // Poultry and Poultry Products. -- 2020. -- No. 6. -- P. 16-20. -- DOI 10.30975/2073-4999-2020-22-6-16-20. -- EDN ZEPPWB.
A clinical case of low pathogenic avian influenza H9N2 at an egg poultry farm / A. V. Varkentin, V. N. Irza, M. S. Volkov, L. A. Demchenko // Poultry and Poultry Products. -- 2020. -- No. 3. -- P. 10-13. -- DOI 10.30975/2073-4999-2020-22-3-10-13. -- EDN DRCGKD.
Comparison of the immunogenic activity of vaccines against low pathogenic avian influenza subtype H9N2 made on the basis of viruses of genetic lines G1 and Y280 / S. V. Frolov, L. O. Shcherbakova, N. V. Moroz [et al.] // Veterinary Today. -- 2021. -- No. 3(38). -- P. 224-229. -- DOI 10.29326/2304-196X-2021-3-38-224-229. -- EDN DQHCCA.
A global perspective on h9n2 avian influenza virus / T. P. Peacock, J. James, J. E. Sealy, M. Iqbal // Viruses. -- 2019. -- Vol. 11, No. 7. -- P. 620. -- DOI 10.3390/v11070620. -- EDN CRZZFS.
Avian influenza vaccines: a practical review in relation to their application in the field with a focus on the Asian experience / M. Peyre, G. Fusheng, S. Desvaux, F. Roger // Epidemiol. Infect, 2009. -- 137 (1). -- Р. 1-21. -- DOI 10.1017/S0950268808001039.
Comparison of the Effectiveness of Two Different Vaccination Regimes for Avian Influenza H9N2 in Broiler Chicken / S. Talat, R. R. Abouelmaatti, R. Almeer, M. M. Abdel-Daim, W. K. Elfeil // ANIMALS, 2020. -- Vol. 10. -- No. 10. --DOI 10.3390/ani10101875.
Evaluation of vaccination strategies to control an avian influenza outbreak in French poultry production networks using EVACS tool / C. Hautefeuille, B. Azzouguen, S. Mouchel, G. Dauphin, M. Peyre // Preventive veterinary medicine, 2020. -- Vol. 184. -- DOI: 10.1016/j.prevetmed.2020.105129.
Spackman, E. Practical aspects of vaccination of poultry against avian influenza virus / E. Spackman, M. J. Pantin-Jackwood // Veterinary Journal, 2014. -- Vol. 202. -- No. 3. -- P. 408-415. -- DOI 10.1016/j.tvjl.2014.09.017.
Status and Challenges for Vaccination against Avian H9N2 Influenza Virus in China / J. Dong, Y. Zhou, J. Pu, L. Liu // Life, 2022. -- 12. -- 1326. -- DOI: 10.3390/life12091326.
The molecular basis of antigenic variation among a(H9N2) avian influenza viruses / T. P. Peacock, W. T. Harvey, J. R. Sadeyen, R. Reeve, M. Iqbal // Emerg Microbes Infect, 2018. -- No. 7;7 (1):176. -- DOI 10.1038/s41426-018-0178-y.