The effect of the regeneration stimulant drug on wound healing and hematological parameters in laboratory animals
УДК: 591.169:612 DOI: 10.31588/2413_4201_1883_2_255_152
Keywords:
wounds, small animals, regenerationAbstract
Most wounds inflicted by animals on each other are bite wounds, other types of injuries are less common. The most common bites in small domestic animals (dogs and cats) are in the ears, back and neck, less often in the limbs and tail. Wounds inflicted by animal teeth are abundantly contaminated with microflora, have uneven edges and often become a serious threat to the animal's life. Given the above, research on the healing process aimed at improving methods of modeling and treating such wounds is extremely relevant. Accurate measurement of the wound surface and standardization of methods for determining the rate of its healing (reduction in size) and calculation of the recovery time of the sick animal are especially important. Also, the study of the main general biological aspects of tissue regeneration is the most important task of modern veterinary medicine and biology and does not lose its relevance. Also, at present, general issues of the pathogenesis of the wound process are being actively studied based on general biological features and pathophysiological aspects of regeneration. The aim of this work was to study the effect of the regeneration stimulator "Sfatro" on the dynamics of the wound process in white rats.
The frequency of skin wounds in animals necessitates acceleration of regeneration and healing, which requires an active search for effective methods of stimulating regeneration. An experiment was conducted to simulate the wound process; it was found that the intensity of wound healing sharply prevailed in the group receiving the drug-stimulator of regeneration "Sfatro". The percentage of reduction of the wound area when using the drug was 44 % on the 7th day, 39.33 % on the 14th day, 18.3 % on the 21st day, 25 %, 20 % and 14 %, respectively, without using the drug. On day 21, the wound area in untreated rats exceeded the wound area of the group receiving the drug by 3.33 times. The use of regeneration stimulators makes it possible to ensure a sufficient level of tissue healing and to have a stimulating effect on the regeneration of the epidermis, which is manifested by shortening the time of epithelization of the wound defect and accelerating stratification.
References
Алексеева, Н. Т. Аналитическая морфология репаративной регенерации в коже под действием различных региональных факторов / Н. Т. Алексеева, Д. Б. Никитюк, С. В. Клочкова // Журнал анатомии и гистопатологии. -- 2015. -- Т 4. -- № 1. -- С. 26-37.
Жданова, О. Б., Сравнительное изучение топографии кишечно-ассоциированной лимфоидной ткани стенки кишечника у песца при гельминтозах / О. Б. Жданова, Л. А. Написанова, Е. В. Репина // Труды Всероссийского НИИ гельминтологии им. К.И. Скрябина. 2006. -- Т. 42. -- С. 131-138.
Кузин, М. И. Раны и раневая инфекция / М.И. Кузин, Б.М. Костюченок. -- М.: Медицина, 1990. -- 20 с.
Попова, Л. Н. Как изменяются границы вновь образующегося эпидермиса при заживлении ран: Автореф. дис канд. мед. наук. -- М., 1942. -- 16 с.
Черкасов, А. В. Способ измерения площадей ран по А. В. Черкасову. / А. В. Черкасов // А. С. 1675657 СССР. № 4645513/28; Заявл. 11.01.1989. Опубл. в Б. И. 11.01.1989.
Abbass, M. Development of a Robust Photogrammetric Metrology System for Monitoring the Healing of Bedsores / M. Abbass, A. Azizi, A. Frank, M. Zolfaghari. // The Photogrammetric Record. -- 2005. -- Vol. 111. -- № 20. -- P. 241.
Cooper, D. M. Human wound assessment: status report and implications for clinicians / D. M. Cooper // Nurs. Stand. -- 2023. -- Vol. 16. -- № 44. -- P. 69-76.
Cees L. Pressure Ulcer surface area measurement using instant full-scale photography and transparency tracings / L. Cees, C. Jody, H. Deannine, De Haan Rob // Advances in Skin & Wound Care. -- 2002. -- Vol. 15. -- № 1. -- P. 17-23.
Flanagan, M. Improving accuracy of wound measurement in clinical practice / M. Flanagan // Ostomy Wound Manage. -- 2003. -- Vol. 49. -- № 10. -- P. 28-40.
Kundin, J. I. A new way to size up a wound / J. I. Kundin // Am. J. Nurs. -- 1989. -- Vol. 89. -- P. 206-207.
Alekseeva, N. T. Analytical morphology of reparative regeneration in the skin under the influence of various regional factors / N. T. Alekseeva, D. B. Nikityuk, S. V. Klochkova // Journal of Anatomy and Histopathology. -- 2015. -- Vol. 4. -- No. 1. -- P. 26-37.
Zhdanova, O. B., Comparative study of the topography of intestinal-associated lymphoid tissue of the intestinal wall in arctic foxes with helminthiasis / O. B. Zhdanova, L. A. Napisanova, E. V. Repina // Proceedings of the All-Russian Research Institute of Helminthology named after K.I. Skryabin. 2006. -- Vol. 42. -- P. 131-138.
Kuzin, M. I. Wounds and wound infection / M.I. Kuzin, B.M. Kostyuchenok. -- M.: Medicine, 1990. -- 20 p.
Popova, L. N. How the boundaries of the newly formed epidermis change during wound healing: Abstract of diss. candidate of medical sciences. -- M., 1942. -- 16 p.
Cherkasov, A. V. Method for measuring wound areas according to A. V. Cherkasov. / A. V. Cherkasov // A. S. 1675657 USSR. No. 4645513/28; Application date 01/11/1989. Published in B. I. 01/11/1989.
Abbass, M. Development of a Robust Photogrammetric Metrology System for Monitoring the Healing of Bedsores / M. Abbass, A. Azizi, A. Frank, M. Zolfaghari. // The Photogrammetric Record. -- 2005. -- Vol. 111. -- No. 20. -- P. 241.
Cooper, D. M. Human wound assessment: status report and implications for clinicians / D. M. Cooper // Nurs. Stand. -- 2023. -- Vol. 16. -- No. 44. -- P. 69-76.
Cees L. Pressure Ulcer surface area measurement using instant full-scale photography and transparency tracings / L. Cees, C. Jody, H. Deannine, De Haan Rob // Advances in Skin & Wound Care. -- 2002. -- Vol. 15. -- No. 1. -- P. 17-23.
Flanagan, M. Improving accuracy of wound measurement in clinical practice / M. Flanagan // Ostomy Wound Manage. -- 2003. -- Vol. 49. -- No. 10. -- P. 28-40.
Kundin, J. I. A new way to size up a wound / J. I. Kundin // Am. J. Nurs. -- 1989. -- Vol. 89. -- P. 206-207.
