STUDY OF TOXICOLOGICAL PROPERTIES OF A NEW MULTI-COMPONENT FEED ADDITIVE
УДК: 614.95 DOI: 10.31588/2413_4201_1883_2_266_106
Keywords:
new feed additive, laboratory animals, irritant effect, diagnostics, embryotoxic effect, teratogenic effectAbstract
The article presents the results of a study of certain toxicological properties of new feed additive "SelEsap". Toxicological evaluation of "SelEsap" feed additive revealed that it was non-irritating to the skin and mucous membranes of eyes of Soviet Chinchilla rabbits. Further studies, conducted on Wistar white rats, focused on effect of the additive on embryonic and postembryonic development at various stages of pregnancy. The evaluation was conducted using modern reproductive diagnostic methods, including microscopy, vaginoscopy, smear analysis and general condition monitoring. Obtained data confirmed the safety of "SelEsap" additive at the studied doses (2000, 4000 and 6000 mg/kg), demonstrating the absence of embryotoxic and teratogenic properties. Furthermore, physiological norms of embryonic development were demonstrated by stable body weight gain in females throughout pregnancy, further confirming the beneficial effects of the additive. Consequently, "SelEsap" feed additive proved to be a safe component at doses up to 6000 mg/kg, having no negative impact on the course of pregnancy, intrauterine development of embryos or subsequent offspring at both the embryonic and postembryonic stages. Based on obtained data, it can be concluded that the new multicomponent feed additive fully complies with biological safety requirements and is recommended for use in poultry diets.
References
Influence of a Complex Feed Additive on the Metabolism and Meat Productivity of Ducks / R. N. Faizrakhmanov, F. F. Zinnatov, V. Milaev [et al.] // Fundamental and Applied Scientific Research in the Development of Agriculture in the Far East (AFE-2022) : Agricultural Cyber-Physical Systems, Ussuriysk, 29 июля 2022 года. Vol. 706-2. Switzerland: Springer Nature Switzerland AG, 2023. -- P. 127-135. https://doi.org/10.1007/978-3-031-36960-5_16. EDN: XEDQQI.
Бобылева Г. А. Российское птицеводство: краткие итоги 60-летнего развития // Птица и птицепродукты. 2025. № 5. С. 6--11.EDN: INNEHE
Османян А. К., Малородов В. В. Создание, становление и развитие Всемирной научной ассоциации по птицеводству (ВНАП) с участием отечественной науки // Птицеводство. 2025. № 1. С. 5-8. EDN: UETPRN.
Assessment of indoor environment to influence the production of gosling broilers when using sanitary litter / R. N. Fayzrakhmanov, V. G. Sofronov, N. I. Danilova, P. V. Sofronov // Bio web of conferences: International Scientific-Practical Conference "Agriculture and Food Security: Technology, Innovation, Markets, Human Resources" (FIES 2020), Kazan, 28--30 мая 2020 года. Vol. 27. EDP Sciences: EDP Sciences, 2020. P. 00053. https://doi.org/10.1051/bioconf/20202700053. EDN: PYSHGK.
Фисинин В. Мировое и отечественное птицеводство: реалии и вызовы будущего // Животноводство России. 2025. № 1. С. 6-13. EDN GEOATN.
Казачкова Н. М., Картекенов К. Ш., Дускаев Г. К. Использование биологически активных веществв кормлении сельскохозяйственной птицы (обзор) // Аграрный вестник Урала. 2024. Т. 24, № 8. С. 1037-1044. https://doi.org/ 10.32417/1997-4868-2024-24-08-1037-1044.
Влияние селена на мясную продуктивность бройлеров / В. В. Саломатин [и др.] // Птица и птицепродукты. 2024. № 2. С. 32--35 EDN: YXLPZK.
Пономаренко Ю. А., Фисинин В. И., Егоров И. А. Научные основы сбалансированного кормления животных: монография. Москва: Перо, 2024. 692 с. EDN: TQZCWK.
Kashaeva Ar., Akhmetzyanova Fk., Khairullin D. D. Toxicological safety assessment of ZeolFat energy feed additive // Bio web of conferences: International Scientific-Practical Conference "Agriculture and Food Security: Technology, Innovation, Markets, Human Resources" (FIES 2020), Kazan, 28--30 мая 2020 года. Vol. 27. EDP Sciences: EDP Sciences, 2020. P. 00086. https://doi.org/10.1051/bioconf/20202700086. EDN: DCCPQU.
Safety and efficacy of a feed additive consisting of a zinc(II)--betaine complex for all animal species (Biochem Zusatzstoffe Handels- und Produktionsges. mbH) / V. Bampidis, G. Azimonti, M. De. L. Bastos [et al.] // European Food Safety Authority Journal. 2023. Vol. 21. No. 2. https://doi.org/10.2903/j.efsa.2023.7819. EDN: MDJYZU.
Fayzrakhmanov RN, Zinnatov FF, Milaev V. Influence of a complex feed additive on the metabolism and meat productivity of ducks. Fundamental and applied scientific research in the development of agriculture in the Far East (AFE-2022): Agricultural Cyber-Physical Systems, Ussuriysk, 29 iyulya 2022 goda. Vol.706-2. Switzerland: Springer Nature Switzerland AG. 2023; 127-135 p. https://doi.org/10.1007/978-3-031-36960-5_16. EDN: XEDQQI.
Bobyleva GA. [Russian poultry farming: brief results of 60 years of development]. Ptitsa i ptitseprodukty. 2025; 5. 6-11 p. EDN: INNEHE
Osmanyan AK, Malorodov VV. [Creation, formation and development of World Scientific Poultry Association (WSPA) with the participation of domestic science]. Ptitsevodstvo. 2025; 1. 5-8 p. EDN: UETPRN.
Fayzrakhmanov RN, Sofronov VG, Danilova NI, Sofronov PV. Assessment of indoor environment to influence the production of gosling broilers when using sanitary litter. Bio web of conferences: International Scientific-Practical Conference "Agriculture and Food Security: Technology, Innovation, Markets, Human Resources" (FIES 2020), Kazan, 28-30 maya 2020 goda. Vol.27. EDP Sciences: EDP Sciences. 2020; 00053 p. https://doi.org/ 10.1051/bioconf/20202700053. EDN: PYSHGK.
Fisinin V. [Global and domestic poultry farming: realities and future challenges]. Zhivotnovodstvo Rossii. 2025; 1. 6-13 p. EDN: GEOATN.
Kazachkova NM, Kartekenov KSh, Duskaev GK. [Use of biologically active substances in poultry feeding (review)]. Agrarnyy vestnik Urala. 2024; Vol.24. 8. 1037-1044 p. https://doi.org/ 10.32417/1997-4868-2024-24-08-1037-1044.
Salomatin VV. [Effect of selenium on meat productivity of broilers]. Ptitsa i ptitseprodukty. 2024; 2. 32-35 p. EDN: YXLPZK
Ponomarenko YuA, Fisinin VI, Egorov IA. Nauchnye osnovy sbalansirovannogo kormleniya zhivotnykh: monografiya. [Scientific foundations of balanced animal feeding: monograph]. Moscow: Pero. 2024; 692 p. EDN TQZCWK.
Kashaeva AR, Akhmetzyanova FK, Khairullin DD. Toxicological safety assessment of ZeolFat energy feed additive. Bio web of conferences: International Scientific-Practical Conference "Agriculture and Food Security: Technology, Innovation, Markets, Human Resources" (FIES 2020), Kazan, 28-30 maya 2020 goda. Vol.27. EDP Sciences: EDP Sciences. 2020; 00086 p. https://doi.org/10.1051/bioconf/20202700086. EDN: DCCPQU.
Bampidis V, Azimonti G., Bastos MDe.L. Safety and efficacy of a feed additive consisting of a zinc(II)--betaine complex for all animal species (Biochem Zusatzstoffe Handels- und Produktionsges. mbH). European Food Safety Authority Journal. 2023; Vol. 21. No. 2. https://doi.org/10.2903/j.efsa.2023.7819. EDN: MDJYZU.
