THE DELTAMETHRIN EFFECT ON THE FUNCTIONAL ACTIVITY OF THE THYROID GLAND IN MOUSE-LIKE RODENTS WITH A SINGLE EXPOSURE
УДК: 612.44:612.018:577.175.44 DOI: 10.31588/2413_4201_1883_2_255_371
Keywords:
thyroid gland, thyroid hormones, synthetic pyrethroids, deltamethrin, northern red-backed vole, ratsAbstract
The research was aimed at evaluating the functional activity of the thyroid gland in mouselike rodents in the case of single exposure to toxic doses of a synthetic pyrethroid deltamethrin.
Deltamethrin at a dose of 1/2 LD50 (43.5 mg/kg body weight for rats and 18.75 mg/kg for northern
red-backed voles) caused thyroid hypofunction in mouse-like rodents, which was manifested by a
decrease in the level of thyroid hormones in the blood serum. Secretion of thyroid-stimulating
hormone increased in rats compensatorily. When male northern red-backed voles were exposed to
deltamethrin, an increase in the ratio of T4/T3 was noted. When rats and female northern red-backed
voles were exposed to the substance, this ratio did not change
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