EVALUATION OF THE PROTEIN PROFILE IN MIXED MYCOTOXICOSIS OF WHITE RATS ON THE BACKGROUND OF APPLICATION PREVENTIVE COMPLEXES
УДК: 619:615.91: 636.084.5: 614.3 DOI: 10.31588/2413_4201_1883_2_258_197
Abstract
Mycotoxins have a negative effect on animals, affecting vital important organs, causing metabolic changes. Mycotoxins are often found in combination, exerting a synergistic or additive interaction on animals. However, the pathogenesis of combined exposure has not been sufficiently studied. An effective way to prevent mycotoxicosis is the use of complex drugs containing substances that have pathogenetic and symptomatic effects. The aim of the research was to study changes in the protein profile of white rats with T-2, afla and zearalenontoxicosis and to evaluate the effectiveness of complex preventive measures. The experiments were conducted on 80 white rats, of both sexes, divided according to the principle of analogues into 8 groups. We used 3 preventive complexes based on sorbents of organic and inorganic origin. Feeding toxic feed to animals led to a violation of the indicators characterizing protein metabolism. A decrease in the total protein content by 32,8 % (P<0,001) and the ratio of protein fractions were recorded: albumin — 42,5 % (P<0,001), globulin — 14,7 % compared to the biological control group. The albumin-globulin coefficient in the animals of the toxic control group was lower than in the biological control group by 32,8 % (P<0,001). The effectiveness of the proposed preventive complexes in experimental T-2, afla and zearalenontoxicosis of white rats was revealed, with priority in the group using the third formulation based on the natural mineral galloisite. The use of preventive complexes at a dose of 0,25 % of the diet had a normalizing effect on protein metabolism.
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