FEATURES OF IRON METABOLISM IN THE ANIMAL BODY AND INFLUENCE OF A PHARMACOLOGICAL COMPOSITION ON THE BASIS OF NANOIRON
УДК: 619. 615.03:577.118 DOI: 10.31588/2413_4201_1883_2_254_168
Keywords:
ron, nano-iron, white rats, calves, iron deficiency conditions, transferrinAbstract
Iron in the animal body plays a crucial role in processes such as hemoglobin synthesis, oxygen transport and cellular respiration, iron is also a component of proteins and enzymes involved in DNA synthesis and cell division, collagen synthesis, nucleic acid replication and recovery, redox reactions, metabolic reactions and body defense. However, despite the vital need for iron, its excess is toxic and its content in the body must be tightly regulated. For the study, three groups of white rats and three groups of calves were formed, 6 animals in each group. The first group of animals served as a control, the second and third groups were subcutaneously injected with a pharmacological composition based on nanoiron at a dose of 50 mg/kg of body weight and 75 mg/kg, respectively. In the studied groups of animals, indicators such as serum iron, total iron-binding capacity and unsaturated iron-binding capacity of serum were evaluated. It has been established that the nanoiron-based compound has a stimulating effect on iron metabolism in animals. An increase in all studied indicators was established. The most optimal dose was 50 mg/kg body weight. A more pronounced stimulating effect was established on the 7th day after the administration of the pharmacological composition.
References
Бахрамов, С. М. Трансферрин: роль в обмене железа и некоторые клинические аспекты / С. М. Бахрамов, Х. М. Казакбаева, А. А. Бугланов // Гематология и трансфузиология. -- 1987. -- Т. 32. -- № 3. -- С. 39-42.
Бугланов, А. А. Определение железосвязывающей способности и трансферрина в сыворотке крови / А. А. Бугланов, Е. В. Саяпина, А. А. Аверьянова // Лабораторное дело. -- 1991. -- № 6. -- С 24-26.
Идельсон, Л. И. К вопросу о выборе метода определения железа в сыворотке и моче / Л. И. Идельсон, Э. Г. Радзивиловская, Л. А. Аполлонов // Проблемы гематологии и переливания крови. -- 1970. -- № 5. -- С. 47-52.
Потемина, Т. Е. Общие вопросы метаболизма железа и патогенеза железодефицитной анемии / Т. Е. Потемина, С. А. Волкова, С. В. Кузнецова, А. В. Перешеин // Вестник медицинского института «Реавиз». -- 2020. -- № 3. -- С. 125-137.
Пудовкин, Н. А. Обмен железа в организме поросят и пути его коррекции / Н. А. Пудовкин, Т. В. Гарипов // Вестник Алтайского государственного аграрного университета. -- 2015. -- № 2 (124). -- С. 49-53.
Трошин, А. Н. Синтез железопротеиновых комплексов как путь повышения эффективности и безопасности ферротерапии животных при железодефицитной анемии / А. Н. Трошин // Ветеринарная практика. -- 2007. -- № 1 (36). -- С. 23-27.
Fernández-Menéndez, S. Searching for enhanced iron fortification of formula milk via nanoparticles and isotope pattern deconvolution / S. Fernández-Menéndez, R. R. A. Peixoto, B. Fernández-Colomer, M. C. Romero, A. Sanz-Medel, M. L. Fernández-Sánchez // Spectrochim Acta Part B. -- 2018. -- V. -- 148 -- P. 165-171.
García-Bañuelos, M. L. Biofortification-promising approach to increasing the content of iron and zinc in staple food crops / M. L. García-Bañuelos, J. P. Sida Arreola, E. Sánchez // J. Elementol. -- 2014 -- V.19. -- Р. 3.
Bakhramov, S. M. Transferrin: role in iron metabolism and some clinical aspects / S. M. Bakhramov, Kh. M. Kazakbaeva, A. A. Buglanov // Hematology and Transfusiology. -- 1987. -- Vol. 32. -- No. 3. -- P. 39-42.
Buglanov, A. A. Determination of iron-binding capacity and transferrin in blood serum / A. A. Buglanov, E. V. Sayapina, A. A. Averyanova // Laboratory Work. -- 1991. -- No. 6. -- P. 24-26.
Idelson, L. I. On the choice of method for determining iron in serum and urine / L. I. Idelson, E. G. Radzivilovskaya, L. A. Apollonov // Problems of Hematology and Blood Transfusion. -- 1970. -- No. 5. -- P. 47-52.
Potemina, T. E. General issues of iron metabolism and pathogenesis of iron deficiency anemia / T. E. Potemina, S. A. Volkova, S. V. Kuznetsova, A. V. Pereshein // Bulletin of the Medical Institute «Reaviz». -- 2020. -- No. 3. -- P. 125-137.
Pudovkin, N. A. Iron metabolism in piglets and ways of its correction / N. A. Pudovkin, T. V. Garipov // Bulletin of Altai State Agrarian University. -- 2015. -- No. 2 (124). -- P. 49-53.
Troshin, A. N. Synthesis of iron-protein complexes as a way to increase the efficiency and safety of ferrotherapy in animals with iron deficiency anemia / A. N. Troshin // Veterinary Practice. -- 2007. -- No. 1 (36). -- P. 23-27.
Fernández-Menéndez, S. Searching for enhanced iron fortification of formula milk via nanoparticles and isotope pattern deconvolution / S. Fernández-Menéndez, R. R. A. Peixoto, B. Fernández-Colomer, M. C. Romero, A. Sanz-Medel, M. L. Fernández-Sánchez // Spectrochim Acta Part B. -- 2018. -- V. -- 148 -- P. 165-171.
García-Bañuelos, M. L. Biofortification-promising approach to increasing the content of iron and zinc in staple food crops / M. L. García-Bañuelos, J. P. Sida Arreola, E. Sánchez // J. Elementol. -- 2014 -- V.19. -- Р. 3.
